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KMID : 1202020150080020230
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Journal of Korean Thyroid Association
2015 Volume.8 No. 2 p.230 ~ p.234
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Interferon-Alpha Induced Severe Hypothyroidism Followed by Graves’ Disease in a Patient Infected with Hepatitis C Virus
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:Kim Kyoung-Jin
:Lee Kang-Won/:Choi Ju-Hee/:An Jee-Hyun
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Abstract
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Interferon-alpha (IFN-α) is an important therapeutic agent for hepatitis C virus (HCV) infection, but has various side effects including thyroiditis. We report a case of interferon-induced non-autoimmune hypothyroidism followed by autoimmune-medicated Graves’ disease. A 59-year-old woman was diagnosed with chronic active hepatitis C; she had been treated with IFN-α and ribavirin for 24 weeks. Before starting the IFN-α, her thyroid function was normal and she was negative for autoantibodies. Severe hypothyroidism developed 5 weeks after halting the IFN-α, with the Graves’ disease phase arising at 32 weeks. For accurate diagnosis and appropriate treatment of thyroid dysfunction during treatment with IFN-α, we need to understand and consider rare cases of multiphasic disorder involving both non-autoimmune and autoimmune thyroiditis induced by IFN-α.
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KEYWORD
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Interferons, Non-autoimmune hypothyroidism, Graves’ disease
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